Result of a multicenter study from Rome, Italy indicate that the biomimetic scaffold that was investigated is an off-the-shelf, cell free, and cost effective implant that can regenerate either cartilage or subchondral bone. The scaffold allows a 1-step surgical procedure that can be used for osteochondral lesions, OCD, and in some cases osteonecrosis.
AJSM July 2014
The outcome of mesenchymal stem cell (MSC) implantation for cartilage repair in osteoarthritis (OA) knees seem encouraging: high BMI and large lesion size are important factors affecting outcomes. Although still in the early stages of application , MSC implantation for cartilage repair may have great potential for the treatment of knee osteoarthritis. However, second look arthroscopic findings revealed that 76% had the repair rated as abnormal or severely abnormal by ICRS standards. The development of an advanced surgical procedure with tissue –engineered scaffolds may be needed to treat patients with large cartilage lesions.
AJSM July 2014
Dr. Malek was the invited speaker at the VI Annual Peruvian Arthroscopy Association which was held July 9-12 in Lima, Peru. An international group of speakers from France, Germany, United Kingdom, Brazil, Belgium, Argentina, Venezuela and Canada were also participated. Topics were the latest in arthroscopic procedures of shoulder, knee and other joints were presented. Over 450 participants were in attendance.
Knee osteoarthritis after anterior cruciate ligament (ACL) injury has previously been reported. However, there has been no meta-analysis reporting the development and progression of osteoarthritis. Authors concluded that ACL injury predisposes knees to osteoarthritis, while ACL reconstruction surgery has a role in reducing the risk of developing degenerative changes at 10 years, however, returning to sports activities after ligament reconstruction may exacerbate the development of arthritis.